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Article

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

The Journal of clinical investigation - 1 Sept 2008

Scheer Nico, Ross Jillian, Rode Anja, Zevnik Branko, Niehaves Sandra, Faust Nicole, Wolf C Roland

Abstract excerpt

The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals. Both receptors regulate the expression of genes involved in the biotransformation of chemicals in a ligand-dependent manner. As the ligand specificity of PXR and CAR have diverged between species, the prediction of in vivo PXR...

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Source

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Identifiers

PMID: 18677425
DOI: 10.1172/JCI35483
PMCID: PMC2493444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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