Article

Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism

2023-04-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> The constitutive androstane receptor (CAR) is a nuclear receptor able to recognize a large panel of xenobiotics leading to the modulation of the expression of its target genes involved in xenobiotic detoxication and energy metabolism. While CAR hepatic activity is thought to be higher in women than in men, its response to an acute pharmacological activation has neve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de1c1e90-bcf6-5a6c-94ee-dc3f5eee0a8a
DOI: 10.1101/2023.04.17.537169

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolismDOI 10.1101/2023.04.17.537169Read

Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: Primary and secondary gene responses with links to disease progressionSemantic proximity Read

From the Cover: Genomic Effects of Androstenedione and Sex-Specific Liver Cancer Susceptibility in Mice.Semantic proximity Read

Sex Differences in the Expression of Drug-Metabolizing and Transporter Genes in Human LiverSemantic proximity Read

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptorSemantic proximity Read

Sex-Biased Expression of Pharmacogenes across Human TissuesSemantic proximity Read

Sex-biased Expression of Pharmacogenes Across Human TissuesSemantic proximity Read

Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety LiabilitiesSemantic proximity Read

Transcriptional Regulation of Cytochrome P450 2B Genes by Nuclear ReceptorsSemantic proximity Read

Inherent sex‐dependent regulation of human hepatic CYP3A5Semantic proximity Read

Pharmacogenetics of the constitutive androstane receptor.Semantic proximity Read

Metabolic modeling of sex-specific tissue predicts mechanisms of differences in toxicological responsesSemantic proximity Read

In Vitro and Vivo Identification, Metabolism and Action of Xenoestrogens: An OverviewSemantic proximity Read