Article
Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations.
Mutation research - 1 Jul 2011
Coelho Millene Borges, Costa Elis Regina Dalla, Vasconcellos Sidra Ezídio Gonçalves, Linck Natali, Ramos Ricardo Martins, Amorim Hermes Luís Neubauer de, Suffys Philip Noel, Santos Adalberto Rezende, Silva Pedro Eduardo Almeida da, Ramos Daniela Fernandes, Silva Márcia Susana Nunes, Rossetti Maria Lucia Rosa
Abstract excerpt
The present study was carried out to investigate the presence of polymorphism in the N-acetyltransferase gene of 41 clinical isolates of Mycobacterium tuberculosis, that were resistant to isoniazid (INH) with no mutations in the hot spots of the genes previously described to be involved in INH resistance (katG, inhA and ahpC). We observed single nucleotide polymorphisms (SNPs) in ten of these, including the G619A...
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