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Article

Mutational and expression analysis of tbnat and its response to isoniazid.

Journal of medical microbiology - 1 Dec 2005

Sholto-Douglas-Vernon Carolyn, Sandy James, Victor Thomas C, Sim Edith, Helden Paul Dvan

Abstract excerpt

A gene (nat) encoding arylamine N-acetyltransferase (NAT) has been found in Mycobacterium tuberculosis. The gene is expressed and the enzyme is active in growing M. tuberculosis cells. N-Acetyltransferase acetylates and inactivates isoniazid (INH), which is a front-line drug used in tuberculosis (TB) therapy. In this study, it was shown that a previously reported G619A single nucleotide polymorphism (SNP) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16278433
DOI: 10.1099/jmm.0.46153-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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