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Article

The pharmacogenetics of NAT: structural aspects.

Pharmacogenomics - 1 Jan 2002

Pompeo Frédérique, Brooke Edward, Kawamura Akane, Mushtaq Adeel, Sim Edith

Abstract excerpt

Arylamine N-acetyltransferases (NATs) catalyze the transfer of an acetyl group from acetyl-CoA to arylhydrazines and to arylamine drugs and carcinogens or to their N-hydroxylated metabolites. NAT plays an important role in detoxification and metabolic activation of xenobiotics and was first identified as the enzyme responsible for inactivation of the antitubercular drug isoniazid, an arylhydrazine. The rate of...

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Identifiers

PMID: 11966400
DOI: 10.1517/14622416.3.1.19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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