Article
Full-gene-sequencing analysis of N-acetyltransferase-2 in an adult Indian population.
Genetic testing and molecular biomarkers - 1 Mar 2013
Tilak Ashwini V, Iyer Sandhya N, Mukherjee Manjari S, Singhal Rekha S, Lele Smita S
Abstract excerpt
AIMS: Drug-metabolizing enzymes play a major role in determining the outcome of drug therapy. N-acetyltransferase-2 (NAT2) is one of the main enzymes involved in metabolism of isoniazid used in treatment of tuberculosis (TB). Several variations in the NAT2 gene give rise to multiple haplotypes that phenotypically code for different acetylator status. The objective was to generate a more unambiguous picture of the...
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