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Article

Acetylation of Isoniazid Is a Novel Mechanism of Isoniazid Resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 16 Dec 2020

Arun K B, Madhavan Aravind, Abraham Billu, Balaji M, Sivakumar K C, Nisha P, Kumar R Ajay

Abstract excerpt

Isoniazid (INH), one of the first-line drugs used for the treatment of tuberculosis, is a prodrug which is activated by the intracellular KatG enzyme of Mycobacterium tuberculosis The activated drug hinders cell wall biosynthesis by inhibiting the InhA protein. INH-resistant strains of M. tuberculosis usually have mutations in katG, inhA, ahpC, kasA, and ndh genes. However, INH-resistant strains which do not have...

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Identifiers

PMID: 33106268
DOI: 10.1128/AAC.00456-20
PMCID: PMC7927840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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