Article
Detection of novel coupled mutations in the katG gene (His276Met, Gln295His and Ser315Thr) in a multidrug-resistant Mycobacterium tuberculosis strain from Chennai, India, and insight into the molecular mechanism of isoniazid resistance using structural bioinformatics approaches.
International journal of antimicrobial agents - 1 Apr 2011
Ramasubban Gayathri, Therese Kulandai Lily, Vetrivel Umashankar, Sivashanmugam Muthukumaran, Rajan Parvathy, Sridhar R, Madhavan Hajib N, Meenakshi N
Abstract excerpt
This study reports on the structural basis of drug resistance targeting the katG gene in a multidrug-resistant Mycobacterium tuberculosis (MDR-TB) strain with two novel mutations (His276Met and Gln295His) in addition to the most commonly reported mutation (Ser315Thr). A structural bioinformatics approach was used to predict the structure of the mutant KatG enzyme (MT). Subsequent molecular dynamics and docking...
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