Article
Arylamine N-acetyltransferases - of mice, men and microorganisms.
Trends in pharmacological sciences - 1 Mar 2001
Upton A, Johnson N, Sandy J, Sim E
Abstract excerpt
Arylamine N-acetyltransferases (NATs) catalyse the transfer of an acetyl group from acetyl CoA to the terminal nitrogen of hydrazine and arylamine drugs and carcinogens. These enzymes are polymorphic and have an important place in the history of pharmacogenetics, being first identified as responsible for the polymorphic inactivation of the anti-tubercular drug isoniazid. NAT has recently been identified within...
Topics
- Alleles
- Animals
- Arylamine N-Acetyltransferase
- Humans
- Mice
- Mutation
- Mycobacterium smegmatis
- Mycobacterium tuberculosis
- Polymorphism, Genetic
- Rabbits
- Rats