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Article

Molecular investigation of active binding site of isoniazid (INH) and insight into resistance mechanism of S315T-MtKatG in Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2017

Srivastava Gaurava, Tripathi Shubhandra, Kumar Akhil, Sharma Ashok

Abstract excerpt

Multi drug resistant tuberculosis is a major threat for mankind. Resistance against Isoniazid (INH), targeting MtKatG protein, is one of the most commonly occurring resistances in MDR TB strains. S315T-MtKatG mutation is widely reported for INH resistance. Despite having knowledge about the mechanism of INH, exact binding site of INH to MtKatG is still uncertain and proposed to have three presumable binding sites...

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Identifiers

PMID: 28610784
DOI: 10.1016/j.tube.2017.04.002

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