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Article

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Apr 2003

Sparreboom Alex, Danesi Romano, Ando Yuichi, Chan Juliana, Figg William D

Abstract excerpt

ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an...

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Source

Identifiers

PMID: 12729805
DOI: 10.1016/s1368-7646(03)00005-0

Genes

ABCB1
ABCC1
ABCC2
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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