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Article

The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.

The Journal of pharmacology and experimental therapeutics - 1 Jun 2008

Abla Nada, Chinn Leslie W, Nakamura Tsutomu, Liu Li, Huang Conrad C, Johns Susan J, Kawamoto Michiko, Stryke Doug, Taylor Travis R, Ferrin Thomas E, Giacomini Kathleen M, Kroetz Deanna L

Abstract excerpt

ABCC4 encodes multidrug resistance protein 4 (MRP4), a member of the ATP-binding cassette family of membrane transporters involved in the efflux of endogenous and xenobiotic molecules. The aims of this study were to identify single nucleotide polymorphisms of ABCC4 and to functionally characterize selected nonsynonymous variants. Resequencing was performed in a large ethnically diverse population. Ten...

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Identifiers

PMID: 18364470
DOI: 10.1124/jpet.108.136523
PMCID: PMC2612728

Genes

ABCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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