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Article

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.

Expert opinion on drug metabolism & toxicology - 1 Oct 2014

Bruhn Oliver, Cascorbi Ingolf

Abstract excerpt

INTRODUCTION: Human ATP-binding cassette (ABC) transporters act as translocators of numerous substrates across extracellular and intracellular membranes, thereby contributing to bioavailability and consequently therapy response. Genetic polymorphisms are considered as critical determinants of expression level or activity and subsequently response to selected drugs. AREAS COVERED: Here the influence of...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Source

Identifiers

PMID: 25162314
DOI: 10.1517/17425255.2014.952630

Genes

ABCB1
ABCC2
ABCC3
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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