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Article

CDK6 kinase activity is required for thymocyte development.

Blood - 9 Jun 2011

Hu Miaofen G, Deshpande Amit, Schlichting Nicolette, Hinds Elisabeth A, Mao Changchuin, Dose Marei, Hu Guo-Fu, Van Etten Richard A, Gounari Fotini, Hinds Philip W

Abstract excerpt

Cyclin-dependent kinase-6 (CDK6) is required for early thymocyte development and tumorigenesis. To mechanistically dissect the role of CDK6 in thymocyte development, we generated and analyzed mutant knock-in mice and found that mice expressing a kinase-dead Cdk6 allele (Cdk6(K43M)) had a pronounced reduction in thymocytes and hematopoietic stem cells and progenitor cells (Lin⁻Sca-1⁺c-Kit⁺ [LSK]). In contrast,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Gene Knock-In Techniques

Share to Hematologic Neoplasms

Share to Interleukin-2 Receptor alpha Subunit

Share to Receptors, Notch

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Source

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Identifiers

PMID: 21508411
DOI: 10.1182/blood-2010-08-300517
PMCID: PMC3122937

Genes

CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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