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Article

A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis

20 Jan 2009

Abstract excerpt

Cyclin-dependent kinase 6 (CDK6) promotes cell cycle progression and is overexpressed in human lymphoid malignancies. To determine the role of CDK6 in development and tumorigenesis, we generated and analyzed knockout mice. Cdk6-deficient mice show pronounced thymic atrophy due to reduced proliferative fractions and concomitant transitional blocks in the double-negative stages. Using the OP9-DL1 system to deliver...

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PMID: 19155308
DOI: 10.1158/0008-5472.can-08-2473

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