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Article

Requirement for deoxycytidine kinase in T and B lymphocyte development

31 Dec 2009

Abstract excerpt

Deoxycytidine kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. dCK phosphorylates and therefore activates nucleoside analog prodrugs frequently used in cancer, autoimmunity, and viral infections. In contrast to its well established therapeutic relevance, the biological function of dCK remains enigmatic. Highest levels of dCK...

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PMID: 20080663
DOI: 10.1073/pnas.0913900107

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