Article
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.
The Journal of experimental medicine - 1 Jun 2015
Thompson Benjamin J, Bhansali Rahul, Diebold Lauren, Cook Daniel E, Stolzenburg Lindsay, Casagrande Anne-Sophie, Besson Thierry, Leblond Bertrand, Désiré Laurent, Malinge Sébastien, Crispino John D
Abstract excerpt
Pre-B and pre-T lymphocytes must orchestrate a transition from a highly proliferative state to a quiescent one during development. Cyclin D3 is essential for these cells' proliferation, but little is known about its posttranslational regulation at this stage. Here, we show that the dual specificity tyrosine-regulated kinase 1A (DYRK1A) restrains Cyclin D3 protein levels by phosphorylating T283 to induce its...
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