Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.

Blood - 9 Oct 2014

Rodríguez-Díez Esther, Quereda Victor, Bellutti Florian, Prchal-Murphy Michaela, Partida David, Eguren Manuel, Kollmann Karoline, Gómez de Cedrón Marta, Dubus Pierre, Cañamero Marta, Martínez Dolores, Sexl Veronika, Malumbres Marcos

Abstract excerpt

Cdk4 and Cdk6 are related protein kinases that bind d-type cyclins and regulate cell-cycle progression. Cdk4/6 inhibitors are currently being used in advanced clinical trials and show great promise against many types of tumors. Cdk4 and Cdk6 are inhibited by INK4 proteins, which exert tumor-suppressing functions. To test the significance of this inhibitory mechanism, we generated knock-in mice that express a Cdk6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 4

Share to Cyclin-Dependent Kinase 6

Share to Cyclin-Dependent Kinase Inhibitor Proteins

Share to Fusion Proteins, bcr-abl

Share to Gene Ontology

Share to Hematopoiesis

Source

Identifiers

PMID: 25157181
DOI: 10.1182/blood-2014-02-555292

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.PMID 25157181Read ↗

CDK6 as a key regulator of hematopoietic and leukemic stem cell activationSemantic proximity Read ↗

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.Semantic proximity Read ↗

Inducible deletion of CDK4 and CDK6 – deciphering CDK4/6 inhibitor effects in the hematopoietic systemSemantic proximity Read ↗

Targeting cell cycle regulators in hematologic malignanciesSemantic proximity Read ↗

CDK6 kinase activity is required for thymocyte development.Semantic proximity Read ↗

Distinct versus redundant properties among members of the INK4 family of cyclin‐dependent kinase inhibitorsSemantic proximity Read ↗

A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and TumorigenesisSemantic proximity Read ↗

Expression of p16Ink4a Compensates for <i>p18Ink4c</i> Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and TissuesSemantic proximity Read ↗

Cyclin-Dependent Kinase Inhibitors in Hematological Malignancies—Current Understanding, (Pre-)Clinical Application and Promising ApproachesSemantic proximity Read ↗

Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair PathwaysSemantic proximity Read ↗

The regulatory role of CDK4/6 inhibitors in tumor immunity and the potential value of tumor immunotherapy (Review)Semantic proximity Read ↗

CDK4 and CDK6 kinases: From basic science to cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.