Article
Cdk2 catalytic activity is essential for meiotic cell division in vivo.
The Biochemical journal - 15 Sept 2016
Chauhan Sangeeta, Diril M Kasim, Lee Joanna H S, Bisteau Xavier, Manoharan Vanessa, Adhikari Deepak, Ratnacaram Chandrahas Koumar, Janela Baptiste, Noffke Juliane, Ginhoux Florent, Coppola Vincenzo, Liu Kui, Tessarollo Lino, Kaldis Philipp
Abstract excerpt
Cyclin-dependent kinases (Cdks) control the eukaryotic cell cycle by phosphorylating serine and threonine residues in key regulatory proteins, but some Cdk family members may exert kinase-independent functions that cannot easily be assessed using gene knockout approaches. While Cdk2-deficient mice display near-normal mitotic cell proliferation due to the compensatory activities of Cdk1 and Cdk4, they are unable...
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