CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.

doi:10.1158/2159-8290.CD-17-0912

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Article

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.

Cancer discovery - 1 Jul 2018

Bellutti Florian, Tigan Anca-Sarmiza, Nebenfuehr Sofie, Dolezal Marlies, Zojer Markus, Grausenburger Reinhard, Hartenberger Svenja, Kollmann Sebastian, Doma Eszter, Prchal-Murphy Michaela, Uras Iris Z, Höllein Alexander, Neuberg Donna S, Ebert Benjamin L, Ringler Anna, Mueller Andre C, Loizou Joanna I, Hinds Philip W, Vogl Claus, Heller Gerwin, Kubicek Stefan, Zuber Johannes, Malumbres Marcos, Farlik Matthias, Villunger Andreas, Kollmann Karoline, Sexl Veronika

Abstract excerpt

Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a stage-specific manner. In early stages, the CDK6 kinase induces a complex transcriptional program to block p53 in hematopoietic cells. Cells lacking CDK6 kinase function are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29899063
DOI: 10.1158/2159-8290.CD-17-0912
PMCID: PMC6031305

Genes

CDK6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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