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Article

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

24 Oct 2014

Abstract excerpt

The cyclin-dependent kinase 6 (CDK6) and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (hematopoietic stem cells [HSCs] and leukemic stem cells [LSCs]) that exceeds its function as a cell-cycle regulator. Although hematopoiesis appears normal under steady-state conditions, Cdk6(-/-) HSCs do not efficiently repopulate...

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Identifiers

PMID: 25342715
DOI: 10.1182/blood-2014-06-584417

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