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Article

Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27.

Cellular and molecular life sciences : CMLS - 1 Apr 2017

Patel Shachi P, Randle Suzanne J, Gibbs Sarah, Cooke Anne, Laman Heike

Abstract excerpt

G1 phase cell cycle proteins, such as cyclin-dependent kinase 6 (Cdk6) and its activating partners, the D-type cyclins, are important regulators of T-cell development and function. An F-box protein, called F-box only protein 7 (Fbxo7), acts as a cell cycle regulator by enhancing cyclin D-Cdk6 complex formation and stabilising levels of p27, a cyclin-dependent kinase inhibitor. We generated a murine model of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27915416
DOI: 10.1007/s00018-016-2427-3
PMCID: PMC5357273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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