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Article

Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Apr 2011

Liu Meng, Blanco-Centurion Carlos, Konadhode RodaRani, Begum Suraiya, Pelluru Dheeraj, Gerashchenko Dmitry, Sakurai Takeshi, Yanagisawa Masashi, van den Pol Anthony N, Shiromani Priyattam J

Abstract excerpt

Cataplexy, a sudden unexpected muscle paralysis, is a debilitating symptom of the neurodegenerative sleep disorder, narcolepsy. During these attacks, the person is paralyzed, but fully conscious and aware of their surroundings. To identify potential neurons that might serve as surrogate orexin neurons to suppress such attacks, the gene for orexin (hypocretin), a peptide lost in most human narcoleptics, was...

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Identifiers

PMID: 21508228
DOI: 10.1523/JNEUROSCI.6069-10.2011
PMCID: PMC3634582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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