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Article

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 May 2004

Beuckmann Carsten T, Sinton Christopher M, Williams S Clay, Richardson James A, Hammer Robert E, Sakurai Takeshi, Yanagisawa Masashi

Abstract excerpt

The sleep disorder narcolepsy has been linked to loss of hypothalamic neurons producing the orexin (hypocretin) neuropeptides. Here, we report the generation of transgenic rats expressing a human ataxin-3 fragment with an elongated polyglutamyl stretch under control of the human prepro-orexin promoter (orexin/ataxin-3 rats). At 17 weeks of age, the transgenic rats exhibited postnatal loss of orexin-positive...

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Identifiers

PMID: 15128861
DOI: 10.1523/JNEUROSCI.5560-03.2004
PMCID: PMC6729432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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