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Article

Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.

Sleep - 1 Sept 2018

Black Sarah Wurts, Sun Jessica D, Santiago Pamela, Laihsu Alex, Kimura Nikki, Yamanaka Akihiro, Bersot Ross, Humphries Paul S

Abstract excerpt

Narcolepsy type 1 (Na-1) and 2 (Na-2) are characterized by an inability to sustain wakefulness and are likely caused by degeneration of orexin neurons. Near complete orexin neurodegeneration depletes orexin-A from the cerebrospinal fluid and produces Na-1. The pathophysiology of Na-2 is less understood but has been hypothesized to be due to less extensive loss of orexin neurotransmission. The orexin-tTA; TetO...

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Source

Identifiers

PMID: 29860347
DOI: 10.1093/sleep/zsy116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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