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Vgll2 and Tead1 Govern Generation of Mouse and Human Hypothalamic Hypocretin (Orexin) Neurons

2026-04-01

Abstract excerpt

<h4>SUMMARY</h4> The hypothalamic hypocretin (Hcrt; aka orexin) neuropeptide neurons are crucial for wakefulness and their malfunction results in narcolepsy; a devastating disorder without current cures. Transplantation of mouse Hcrt cells into mouse narcolepsy models is pointing to cell therapy as a potential treatment for narcolepsy. However, progress in this area requires decoding the developmental pathways ge...

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Literature Corpus work
bf9629c0-51c4-5867-8d4e-250b60b4c159
DOI
10.64898/2026.03.30.715421
Open publication

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