Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The development of sleep/wake disruption and cataplexy as hypocretin/orexin neurons degenerate in male vs. female Orexin/tTA; TetO-DTA Mice.

Sleep - 12 Dec 2022

Sun Yu, Tisdale Ryan, Park Sunmee, Ma Shun-Chieh, Heu Jasmine, Haire Meghan, Allocca Giancarlo, Yamanaka Akihiro, Morairty Stephen R, Kilduff Thomas S

Abstract excerpt

Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been created to model this disorder and are increasingly being used for preclinical drug development and basic science studies, yet most studies have solely used male mice. We compared the development of narcoleptic symptomatology in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Narcolepsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurons

Share to Orexins

Share to Phenotype

Share to Wakefulness

Source

Open in PubMed Open full text

Identifiers

PMID: 35182424
DOI: 10.1093/sleep/zsac039
PMCID: PMC9742901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The development of sleep/wake disruption and cataplexy as hypocretin/orexin neurons degenerate in male vs. female Orexin/tTA; TetO-DTA Mice.PMID 35182424Read ↗

The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female <i>Orexin/tTA; TetO-DTA</i> MiceSemantic proximity Read ↗

Behavioral and sleep/wake characteristics of mice lacking norepinephrine and hypocretin.Semantic proximity Read ↗

Sleep, sleep disorders and hypocretin (orexin).Semantic proximity Read ↗

Sleep and cardiovascular phenotype in middle-aged hypocretin-deficient narcoleptic mice.Semantic proximity Read ↗

Partial ablation of the orexin field induces a sub narcoleptic phenotype in a conditional mouse model of orexin neurodegenerationSemantic proximity Read ↗

Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.Semantic proximity Read ↗

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.Semantic proximity Read ↗

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat.Semantic proximity Read ↗

Dual Orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexySemantic proximity Read ↗

TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models.Semantic proximity Read ↗

Effect of ambient temperature on sleep breathing phenotype in mice: the role of orexins.Semantic proximity Read ↗

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.