Article

The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female <i>Orexin/tTA; TetO-DTA</i> Mice

2021-10-15

Abstract excerpt

Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been created to model this disorder and are increasingly being used for preclinical drug development and basic science studies, yet most studies have solely used male mice. We compared the development of narcoleptic symptomatology in...

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Literature Corpus work: 49e523d4-e4c8-50fc-86c6-b3ee8475dc9d
DOI: 10.1101/2021.10.13.463880

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