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Article

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.

The Journal of clinical investigation - 1 Feb 2014

Hasegawa Emi, Yanagisawa Masashi, Sakurai Takeshi, Mieda Michihiro

Abstract excerpt

The loss of orexin neurons in humans is associated with the sleep disorder narcolepsy, which is characterized by excessive daytime sleepiness and cataplexy. Mice lacking orexin peptides, orexin neurons, or orexin receptors recapitulate human narcolepsy phenotypes, further highlighting a critical role for orexin signaling in the maintenance of wakefulness. Despite the known role of orexin neurons in narcolepsy,...

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Identifiers

PMID: 24382351
DOI: 10.1172/JCI71017
PMCID: PMC3904620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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