Article

Dual Orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy

2019-12-19

Abstract excerpt

<h4>Summary</h4> Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the tuberal hypothalamus and project throughout the brain to regulate sleep/wakefulness. Ablation of orexin neurons in mice decreases wakefulness and results in a narcolepsy-like phenotype, whereas ablation of MCH neurons increases wakefulness. Since it is unclear how orexin and MCH neurons i...

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Literature Corpus work: c9e5c149-f6c5-5300-82cf-6fc0c2b2f4b3
DOI: 10.1101/2019.12.17.880229

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