Article
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2016
Bernard-Valnet Raphaël, Yshii Lidia, Quériault Clémence, Nguyen Xuan-Hung, Arthaud Sébastien, Rodrigues Magda, Canivet Astrid, Morel Anne-Laure, Matthys Arthur, Bauer Jan, Pignolet Béatrice, Dauvilliers Yves, Peyron Christelle, Liblau Roland S
Abstract excerpt
Narcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of orexinergic neurons in the lateral hypothalamus. The genetic and environmental factors associated with narcolepsy, together with serologic data, collectively point to an autoimmune origin. The current animal models of narcolepsy, based on either disruption of the orexinergic neurotransmission or neurons, do not allow study...
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