Article

Animal Models of Narcolepsy: From Hypocretin Deficiency to Immune Mechanisms and Regenerative Therapies

2025-10-04

Abstract excerpt

Animal models have been pivotal in uncovering the hypocretin (orexin) system as the fulcrum of sleep–wake regulation and in shaping therapeutic discovery for narcolepsy. Early canine and murine models established that hypocretin loss underlies narcolepsy type 1, while conditional and receptor-specific manipulations refined mechanistic insight. However, current paradigms capture only fragments of the human phenotyp...

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Literature Corpus work: 5881c479-6b86-5ee6-afa9-164eb1577f9b
DOI: 10.20944/preprints202510.0265.v1

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