Differential microRNA regulation of HLA-C expression and its association with HIV control.

doi:10.1038/nature09914

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Article

Differential microRNA regulation of HLA-C expression and its association with HIV control.

Nature - 28 Apr 2011

Kulkarni Smita, Savan Ram, Qi Ying, Gao Xiaojiang, Yuki Yuko, Bass Sara E, Martin Maureen P, Hunt Peter, Deeks Steven G, Telenti Amalio, Pereyra Florencia, Goldstein David, Wolinsky Steven, Walker Bruce, Young Howard A, Carrington Mary

Abstract excerpt

The HLA-C locus is distinct relative to the other classical HLA class I loci in that it has relatively limited polymorphism, lower expression on the cell surface, and more extensive ligand-receptor interactions with killer-cell immunoglobulin-like receptors. A single nucleotide polymorphism (SNP) 35 kb upstream of HLA-C (rs9264942; termed -35) associates with control of HIV, and with levels of HLA-C messenger RNA...

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PMID: 21499264
DOI: 10.1038/nature09914
PMCID: PMC3084326

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