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Article

Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes.

Frontiers in immunology - 1 Jan 2024

Arumugam Thilona, Adimulam Theolan, Gokul Anmol, Ramsuran Veron

Abstract excerpt

Variation within the non-coding genome may influence the regulation and expression of important genes involved in immune control such as the human leukocyte antigen (HLA) system. Class I and Class II HLA molecules are essential for peptide presentation which is required for T lymphocyte activation. Single nucleotide polymorphisms within non-coding regions of HLA Class I and Class II genes may influence the...

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Variation

Share to HLA Antigens

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Share to Polymorphism, Single Nucleotide

Share to RNA, Untranslated

Source

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Identifiers

PMID: 39355248
DOI: 10.3389/fimmu.2024.1422834
PMCID: PMC11442197

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