Article
Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease.
Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2013
Kulkarni Smita, Qi Ying, O'hUigin Colm, Pereyra Florencia, Ramsuran Veron, McLaren Paul, Fellay Jacques, Nelson George, Chen Haoyan, Liao Wilson, Bass Sara, Apps Richard, Gao Xiaojiang, Yuki Yuko, Lied Alexandra, Ganesan Anuradha, Hunt Peter W, Deeks Steven G, Wolinsky Steven, Walker Bruce D, Carrington Mary
Abstract excerpt
Variation in the 3' untranslated region (3'UTR) of the HLA-C locus determines binding of the microRNA Hsa-miR-148a, resulting in lower cell surface expression of alleles that bind miR-148a relative to those alleles that escape its binding. The HLA-C 3'UTR variant was shown to associate with HIV control, but like the vast majority of disease associations in a region dense with causal candidates, a direct effect of...
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