Article
A single nucleotide polymorphism -35 kb T>C (rs9264942) is strongly associated with psoriasis vulgaris depending on HLA-Cw(∗)06.
Human immunology - 1 Jun 2014
Majorczyk Edyta, Matusiak Lukasz, Nowak Izabela, Pietkiewicz-Sworowska Aneta, Luszczek Wioleta, Szepietowski Jacek C, Kuśnierczyk Piotr
Abstract excerpt
HLA class I molecules play a role both in viral infection control and in autoimmune diseases development. rs9264942T>C polymorphism in HLA-C gene was found to impact on HLA-C surface expression level and to be associated with HIV-1 control. It was found that these HLA alleles which protect against AIDS are associated with autoimmune disease e.g. psoriasis vulgaris (PsV). Whether rs9264942 SNP is associated with...
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