Article
Polymorphic differences within HLA-C alleles contribute to alternatively spliced transcripts lacking exon 5.
HLA - 1 Sept 2022
Ehlers Femke A I, Olieslagers Timo I, Groeneweg Mathijs, Bos Gerard M J, Tilanus Marcel G J, Voorter Christina E M, Wieten Lotte
Abstract excerpt
The HLA genes are amongst the most polymorphic in the human genome. Alternative splicing could add an extra layer of complexity, but has not been studied extensively. Here, we applied an RNA based approach to study the influence of allele polymorphism on alternative splicing of HLA-C in peripheral blood. RNA was isolated from these peripheral cells, converted into cDNA and amplified specifically for 12 common...
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