Genetic variability in markers of HLA-C expression in two diverse South African populations.

doi:10.1371/journal.pone.0067780

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic variability in markers of HLA-C expression in two diverse South African populations.

PloS one - 1 Jan 2013

Gentle Nikki L, Paximadis Maria, Puren Adrian, Tiemessen Caroline T

Abstract excerpt

An insertion-deletion (indel) polymorphism within the 3' untranslated region (UTR) of HLA-C has been shown to be involved in the regulation of HLA-C expression. Individuals who carry a deletion at this position exhibit increased HLA-C expression, which associates with lower viral set point in HIV-1 infected individuals. This 263 indel (rs67384697) is reported to be in strong linkage disequilibrium (LD) with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black People

Share to HLA-C Antigens

Share to INDEL Mutation

Share to Linkage Disequilibrium

Share to Population Surveillance

Share to South Africa

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 23861805
DOI: 10.1371/journal.pone.0067780
PMCID: PMC3702582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variability in markers of HLA-C expression in two diverse South African populations.PMID 23861805Read ↗

Differential microRNA regulation of HLA-C expression and its association with HIV control.Semantic proximity Read ↗

Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.Semantic proximity Read ↗

HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.Semantic proximity Read ↗

Influence of HLA-C expression level on HIV control.Semantic proximity Read ↗

Structural and regulatory diversity shape HLA-C protein expression levels.Semantic proximity Read ↗

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.Semantic proximity Read ↗

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease.Semantic proximity Read ↗

Hla-C genetic diversity and evolutionary insights in two samples from Brazil and Benin.Semantic proximity Read ↗

Worldwide genetic variation at the 3′ untranslated region of the HLA-G gene: balancing selection influencing genetic diversitySemantic proximity Read ↗

High frequency of HIV mutations associated with HLA-C suggests enhanced HLA-C-restricted CTL selective pressure associated with an AIDS-protective polymorphism.Semantic proximity Read ↗

Lack of association of KIR2DL1-R245 and KIR2DL1-C245 with HIV-1 control in black South Africans with HLA-C2.Semantic proximity Read ↗

HLA-E coding and 3' untranslated region variability determined by next-generation sequencing in two West-African population samples.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.