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Article

High frequency of HIV mutations associated with HLA-C suggests enhanced HLA-C-restricted CTL selective pressure associated with an AIDS-protective polymorphism.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2012

Blais Marie-Eve, Zhang Yonghong, Rostron Tim, Griffin Harry, Taylor Stephen, Xu Keyi, Yan Huiping, Wu Hao, James Ian, John Mina, Dong Tao, Rowland-Jones Sarah L

Abstract excerpt

Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag. This polymorphism was recently shown to be a marker for a protective variant in the 3'UTR of HLA-C that disrupts a microRNA binding site, resulting in enhanced HLA-C expression at the cell surface. Whether individuals with "high" HLA-C...

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Identifiers

PMID: 22474021
DOI: 10.4049/jimmunol.1103472
PMCID: PMC3378658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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