Article
Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.
Journal of virology - 1 Apr 2011
Corrah Tumena W, Goonetilleke Nilu, Kopycinski Jakub, Deeks Steven G, Cohen Myron S, Borrow Persephone, McMichael Andrew, Brackenridge Simon
Abstract excerpt
Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the -35 SNP...
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