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Article

Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.

Journal of virology - 1 Apr 2011

Corrah Tumena W, Goonetilleke Nilu, Kopycinski Jakub, Deeks Steven G, Cohen Myron S, Borrow Persephone, McMichael Andrew, Brackenridge Simon

Abstract excerpt

Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low...

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Share to Gene Expression
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Share to HLA-C Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Share to Regulatory Elements, Transcriptional

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Source

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Identifiers

PMID: 21248048
DOI: 10.1128/JVI.02276-10
PMCID: PMC3067890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21248048-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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