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Article

Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.

Pharmacogenomics - 1 Nov 2011

Mortensen Holly M, Froment Alain, Lema Godfrey, Bodo Jean-Marie, Ibrahim Muntaser, Nyambo Thomas B, Omar Sabah A, Tishkoff Sarah A

Abstract excerpt

UNLABELLED: Functional variability at the arylamine N-acetyltransferase genes is associated with drug response in humans and may have been adaptive in the past owing to selection pressure from diet and exposure to toxins during human evolution. AIMS: We have characterized nucleotide variation at the NAT1 and NAT2 genes, and at the NATP1 pseudogene in global human populations, including many previously...

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Identifiers

PMID: 21995608
DOI: 10.2217/pgs.11.88
PMCID: PMC4653814

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.PMID 21995608Read ↗

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Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.Semantic proximity Read ↗

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