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Article

Spliceosome assembly in the absence of stable U4/U6 RNA pairing.

RNA (New York, N.Y.) - 1 May 2015

Burke Jordan E, Butcher Samuel E, Brow David A

Abstract excerpt

The cycle of spliceosome assembly, intron excision, and spliceosome disassembly involves large-scale structural rearrangements of U6 snRNA that are functionally important. U6 enters the splicing pathway bound to the Prp24 protein, which chaperones annealing of U6 to U4 RNA to form a U4/U6 di-snRNP. During catalytic activation of the assembled spliceosome, U4 snRNP is released and U6 is paired to U2 snRNA. Here we...

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Identifiers

PMID: 25762536
DOI: 10.1261/rna.048421.114
PMCID: PMC4408799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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