Article
Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs.
Genes & development - 1 May 1991
Shannon K W, Guthrie C
Abstract excerpt
U4 and U6 small nuclear RNAs are associated by an extensive base-pairing interaction that must be disrupted and reformed with each round of splicing. U4 mutations within the U4/U6 interaction domain destabilize the complex in vitro and cause a cold-sensitive phenotype in vivo. Restabilization of the U4/U6 helix by dominant (gain-of-function), compensatory mutations in U6 results in wild-type growth....
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