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Article

A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.

Genes & development - 1 Jan 1994

Fortner D M, Troy R G, Brow D A

Abstract excerpt

U6 small nuclear RNA (snRNA) is an essential component of the spliceosome, the ribonucleoprotein complex that carries out the splicing of pre-mRNAs. The precise function of U6 RNA is unknown, but it has been proposed to participate directly in catalysis of the splicing reaction. We present biochemical and genetic evidence for an intramolecular stem/loop structure in the 3' half of U6 RNA of the yeast...

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Identifiers

PMID: 8299941
DOI: 10.1101/gad.8.2.221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.PMID 8299941Read ↗

A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.Semantic proximity Read ↗

Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs.Semantic proximity Read ↗

Multiple roles for U6 snRNA in the splicing pathway.Semantic proximity Read ↗

Interactions of the yeast U6 RNA with the pre-mRNA branch site.Semantic proximity Read ↗

A spontaneous duplication in U6 spliceosomal RNA uncouples the early and late functions of the ACAGA element in vivo.Semantic proximity Read ↗

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.Semantic proximity Read ↗

Brr2p-mediated unwinding of U4/U6 is promoted by a mutually exclusive intra-molecular stem loop in U4 and involves destabilization of the 5’ stem-loop of U4Semantic proximity Read ↗

Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome.Semantic proximity Read ↗

In vitro reconstitution of yeast splicing with U4 snRNA reveals multiple roles for the 3' stem-loop.Semantic proximity Read ↗

Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.Semantic proximity Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

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