Article
Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1.
Nucleic acids research - 30 Nov 2018
Nomura Yuichiro, Roston Daniel, Montemayor Eric J, Cui Qiang, Butcher Samuel E
Abstract excerpt
Post-transcriptional modification of snRNA is central to spliceosome function. Usb1 is an exoribonuclease that shortens the oligo-uridine tail of U6 snRNA, resulting in a terminal 2',3' cyclic phosphate group in most eukaryotes, including humans. Loss of function mutations in human Usb1 cause the rare disorder poikiloderma with neutropenia (PN), and result in U6 snRNAs with elongated 3' ends that are aberrantly...
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