Article
Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.
PLoS genetics - 1 Apr 2011
Addinall Stephen Gregory, Holstein Eva-Maria, Lawless Conor, Yu Min, Chapman Kaye, Banks A Peter, Ngo Hien-Ping, Maringele Laura, Taschuk Morgan, Young Alexander, Ciesiolka Adam, Lister Allyson Lurena, Wipat Anil, Wilkinson Darren James, Lydall David
Abstract excerpt
To better understand telomere biology in budding yeast, we have performed systematic suppressor/enhancer analyses on yeast strains containing a point mutation in the essential telomere capping gene CDC13 (cdc13-1) or containing a null mutation in the DNA damage response and telomere capping gene YKU70 (yku70Δ). We performed Quantitative Fitness Analysis (QFA) on thousands of yeast strains containing mutations...
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