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Article

The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p.

Genetics - 1 Nov 2007

Petreaca Ruben C, Chiu Huan-Chih, Nugent Constance I

Abstract excerpt

The function of telomeres is twofold: to facilitate complete chromosome replication and to protect chromosome ends against fusions and illegitimate recombination. In the budding yeast Saccharomyces cerevisiae, interactions among Cdc13p, Stn1p, and Ten1p are thought to be critical for promoting these processes. We have identified distinct Stn1p domains that mediate interaction with either Ten1p or Cdc13p, allowing...

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Source

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Identifiers

PMID: 17947422
DOI: 10.1534/genetics.107.078840
PMCID: PMC2147953

Genes

STN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p.PMID 17947422Read ↗

Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.Semantic proximity Read ↗

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.Semantic proximity Read ↗

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.Semantic proximity Read ↗

Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Semantic proximity Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

Cdc13 both positively and negatively regulates telomere replication.Semantic proximity Read ↗

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.Semantic proximity Read ↗

Overlapping open reading frames strongly reduce human and yeast STN1 gene expression and affect telomere function.Semantic proximity Read ↗

Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.Semantic proximity Read ↗

Dysfunction of Telomeric Cdc13-Stn1-Ten1 Simultaneously Activates DNA Damage and Spindle Checkpoints.Semantic proximity Read ↗

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.Semantic proximity Read ↗

Linear chromosome maintenance in the absence of essential telomere-capping proteins.Semantic proximity Read ↗

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