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Article

New reporters for monitoring cellular NMD.

RNA (New York, N.Y.) - 18 Mar 2025

Alalam Hanna, Šafhauzer Monika, Sunnerhagen Per

Abstract excerpt

Nonsense-mediated decay (NMD) is a eukaryotic surveillance pathway that controls degradation of cytoplasmic transcripts with aberrant features. NMD-controlled RNA degradation acts to regulate a large fraction of the mRNA population. It has been implicated in cellular responses to infections and environmental stress, as well as in deregulation of tumor-promoting genes. NMD is executed by a set of three core...

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Identifiers

PMID: 39880586
DOI: 10.1261/rna.080272.124
PMCID: PMC11912909

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UPF1

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