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Article

A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.

Cell - 24 Mar 2006

Downey Michael, Houlsworth Rebecca, Maringele Laura, Rollie Adrienne, Brehme Marc, Galicia Sarah, Guillard Sandrine, Partington Melanie, Zubko Mikhajlo K, Krogan Nevan J, Emili Andrew, Greenblatt Jack F, Harrington Lea, Lydall David, Durocher Daniel

Abstract excerpt

Telomere capping is the essential function of telomeres. To identify new genes involved in telomere capping, we carried out a genome-wide screen in Saccharomyces cerevisiae for suppressors of cdc13-1, an allele of the telomere-capping protein Cdc13. We report the identification of five novel suppressors, including the previously uncharacterized gene YML036W, which we name CGI121. Cgi121 is part of a conserved...

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PMID: 16564010
DOI: 10.1016/j.cell.2005.12.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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