Article

Systematic analysis of the effects of the DNA damage response network in telomere defective budding yeast

2017-01-18

Abstract excerpt

Functional telomeres are critically important to eukaryotic genetic stability. Budding yeast is a powerful model organism for genetic analysis and yeast telomeres are maintained by very similar mechanisms to human telomeres. Scores of proteins and pathways are known to affect telomere function. Here, we report a series of related genome-wide genetic interaction screens performed on budding yeast cells with acute o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85da0e35-4e81-550b-bfd7-b342f2ffcb6e
DOI: 10.1101/101253

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic analysis of the effects of the DNA damage response network in telomere defective budding yeastDOI 10.1101/101253Read

Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast.Semantic proximity Read

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read

Survival and Growth of Yeast without Telomere Capping by Cdc13 in the Absence of Sgs1, Exo1, and Rad9Semantic proximity Read

Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.Semantic proximity Read

Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants.Semantic proximity Read

Genomic stability disorders: from budding yeast to humans.Semantic proximity Read

Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.Semantic proximity Read

Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.Semantic proximity Read

Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.Semantic proximity Read

Comprehensive synthetic genetic array analysis of alleles that interact with mutation of the <i>Saccharomyces cerevisiae</i> RecQ helicases Hrq1 and Sgs1Semantic proximity Read

A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.Semantic proximity Read

Mec1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.Semantic proximity Read